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Biology Seminar: Crystal Rogers, University of California, Davis

Friday, February 12, 2021 4:10pm to 5:00pm

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Crystal Rogers, University of California, Davis School of Veterinary Medicine

"Sticking together: Cadherin proteins during embryonic development"

Science Trivia- 4pm
Talk Begins- 4:10pm

Abstract: Neural crest cells are multipotent embryonic cells that form melanocytes, craniofacial bone and cartilage, and the peripheral nervous system in vertebrates. Dynamic neural crest cells transition between epithelial and mesenchymal states by altering expression of cell-cell adhesion proteins (cadherins), which control their specification, epithelial to mesenchymal transition (EMT), migration, and mesenchymal to epithelial transition. Abnormal neural crest development leads to congenital anomalies including craniofacial clefts as well as neural crest-derived cancers. Here, we identify the role of the type II cadherin protein, Cadherin-11 (CDH11), in early chicken development. Our findings reveal an early requirement for CDH11 in neural crest specification, survival, and transition to a migratory phase. These findings reveal a novel role for cell adhesion proteins in neural crest cell survival and may increase our understanding of early cadherin-related NC developmental defects.

Open to the public (contact gonyerk@reed.edu for the Zoom link & password)

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