Crystal Carr, PhD, University of Michigan

Exploring a Novel Model of Cocaine Addiction

The psychomotor activating effects of psychomotor stimulant drugs, such as cocaine or amphetamine, can change in very different ways – showing tolerance or sensitization – depending on whether they are administered intermittently, or not. This behavioral plasticity is thought to reflect, at least in part, changes in dopamine (DA) neurotransmission, and therefore, may provide insights into how repeated drug use promotes the development of substance use disorders. Indeed, the most widely used preclinical model of cocaine addiction, which involves Long Access (LgA) self-administration procedures, is reported to produce tolerance to cocaine’s psychomotor activating effects and effects on DA activity. In contrast, Intermittent Access (IntA; the novel model) cocaine self-administration is more effective than LgA in producing addiction-like behavior but sensitizes DA neurotransmission. There is very little information concerning the effects of IntA experience on the psychomotor activating effects of cocaine. The purpose of the studies I will discuss, therefore, was to determine whether IntA experience produces psychomotor sensitization with similar characteristics to that produced by the intermittent, noncontingent administration of cocaine. I will specifically focus on the effects of withdrawal, sex, and cross-sensitization. 

Tuesday, February 25, 2020 at 4:30pm to 5:30pm

Psychology, 103
3203 SE Woodstock Blvd, Portland, OR 97202, USA

Event Type



Faculty, Students, Staff

Biology, Psychology
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