Exploring a Novel Model of Cocaine Addiction
The psychomotor activating effects of psychomotor stimulant drugs, such as cocaine or amphetamine, can change in very different ways – showing tolerance or sensitization – depending on whether they are administered intermittently, or not. This behavioral plasticity is thought to reflect, at least in part, changes in dopamine (DA) neurotransmission, and therefore, may provide insights into how repeated drug use promotes the development of substance use disorders. Indeed, the most widely used preclinical model of cocaine addiction, which involves Long Access (LgA) self-administration procedures, is reported to produce tolerance to cocaine’s psychomotor activating effects and effects on DA activity. In contrast, Intermittent Access (IntA; the novel model) cocaine self-administration is more effective than LgA in producing addiction-like behavior but sensitizes DA neurotransmission. There is very little information concerning the effects of IntA experience on the psychomotor activating effects of cocaine. The purpose of the studies I will discuss, therefore, was to determine whether IntA experience produces psychomotor sensitization with similar characteristics to that produced by the intermittent, noncontingent administration of cocaine. I will specifically focus on the effects of withdrawal, sex, and cross-sensitization.
Tuesday, February 25, 2020 at 4:30pm to 5:30pm
3203 SE Woodstock Blvd, Portland, OR 97202, USA
Reed Community Members
If you are a member of the Reed community, you MUST LOG IN to see events that are open ONLY to the Reed community. Log in with your Reed ID (your Kerberos account information). If you don’t remember your account username or password, go to reed.edu/cis/help/kerberos.html.Log in with Reed ID