Chemistry Seminar: Spring/Fall Senior Research Presentation

Please join the chemistry department for a presentation of senior thesis research on December 5th at 4:15 pm in Biology 19.

Dorothy Cheng

Biochemistry and Molecular Biology, Spring/Fall Class of 2019

"Structural and Biochemical Characterization of NiaR"

NAD biosynthesis and bioregulation play a large role in the metabolism of both prokaryotes and eukaryotes. NiaR is a DNA-binding transcription regulator in bacteria that represses NAD biosynthesis in the presence of nicotinic acid (NA), a precursor of NAD biosynthesis. I characterized Thermotoga maritima (tm) NiaR as an iron metalloprotein. The crystal structure of tmNiaR shows that the iron ion coordinates the binding of NA by interacting with the pyridine nitrogen. From the structural and biochemical characterization of NiaR, I hypothesize that NiaR exists in a monomer-dimer equilibrium, and that the presence of NA is thought to drive NiaR dimerization which is favorable for DNA operator binding. 

Thursday, December 5, 2019 at 4:15pm to 5:00pm

Biology, 19
3203 Southeast Woodstock Boulevard, Portland, Oregon 97202-8199

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