Chemistry Seminar: "Surface Modification Toward a Novel Cardiovascular Stent"

Dr. Casey Jones '05 an assistant professor of organic chemistry at Lewis & Clark College. Her research focuses on synthesizing compounds found in wine and berries, attaching these compounds to the surface of medical devices, and testing the effect of these compounds on the growth and migration of cells found in the cardiovascular system. The goal of this work is to improve the body’s healing response after the implantation of a stent, a medical device used to reopen narrow arteries found in patients with coronary heart disease.

 

"Surface Modification Toward a Novel Cardiovascular Stent"

Cardiovascular stents are used to treat coronary artery disease by physically opening narrowed arteries. However, cellular damage caused before and during implantation can lead to dangerous complications. Resveratrol is a polyphenol antioxidant found to assist arterial healing after exposure to stress conditions. My lab is investigating whether attaching resveratrol to the surface of a bare metal stent will improve the speed and extent of arterial healing. To attach these compounds in a robust covalent manner, zirconium vapor deposition on stainless steel samples is performed by undergraduate researchers in my lab to form a stable but reactive zirconium oxide "glue" layer. This zirconium oxide layer enables the covalent attachment of resveratrol directly to the surface. Alternatively, organic linker molecules capable of bonding to molecules like resveratrol have been attached to the stainless-steel surface. After synthesis and characterization, we have seeded surfaces with human aortic endothelial cells to examine cell proliferation and healing in oxidative stress conditions common in cardiovascular disease.

Thursday, October 3, 2019 at 4:15pm to 5:00pm

Biology, 19
3203 Southeast Woodstock Boulevard, Portland, Oregon 97202-8199

Event Type

Lecture

Audience

Faculty, Students, Alumni, Open to the Public

Department
Chemistry
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