Chemistry Seminar: André Isaacs, Ph.D. "A Click Chemistry Approach to Nitrogen Heterocycles"
Thursday, March 2, 2023 4:15pm to 5pm
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Thursday, March 2, 2023 4:15pm to 5pm
About this Event
3203 Southeast Woodstock Boulevard, Portland, Oregon 97202-8199
Dr. André Isaacs (he/him/his) is an Associate Professor of Chemistry at the College of the Holy Cross in Worcester, MA. He moved to the U.S. upon finishing high school in Kingston, Jamaica and received his B.A. from the College of the Holy Cross and his PhD from the University of Pennsylvania. He then worked as a postdoctoral research associate at the University of California, Berkeley before accepting his current faculty position. In addition to teaching courses in Organic Chemistry, he conducts and publishes research in the area of copper-mediated organic reactions and synthesis. He is a faculty advisor to numerous student groups including the Caribbean African Students’ Assemblage and is a member of the college’s GLBTQ Faculty and Staff Alliance.
A Click Chemistry Approach to Nitrogen Heterocycles
Our research interests are centered on a very reliable organic reaction - the copper-catalyzed cycloaddition of sulfonyl azides and terminal alkynes (CuAAC). Differential fragmentation of the resulting 1,2,3-triazole generates ketenimines and rhodium carbenoids which readily engage with a variety of nucleophiles to gain access to heterocycles of interest to the synthetic community. Herein, we demonstrate the utility of click chemistry in the synthesis of N-Heterocycles such as indolizines, dihydroisoquinolines and beta-lactams.
This event is supported by the Thomas Dunne Lecture Fund.
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