Login with your Reed credentials to view all events.

{Virtual} Biology Talk: Haleh Fotowat, Harvard Univeristy

Friday, October 1, 2021 4:10pm to 5:00pm

Add to calendar

The overarching goal of Dr. Haleh Fotowat's research is to discover neural mechanisms that underlie sensory-evoked natural behaviors. Specifically, she is interested in characterizing neural mechanisms that link an animal’s behavioral response to its past experience and internal state.

"From Drains to Wrappers: Anatomical and Molecular Characterization of the Zebrafish Meninges"

Science Trivia- 4pm
Talk Begins- 4:10pm

The CNS is enveloped by shielding membranes called the meninges that protect it against mechanical shock, maintain brain buoyancy, and, importantly, supply nutrients, remove waste, transport immune cells, and help maintain brain homeostasis via abundant blood and lymphatic vessels. Despite their importance, the cellular composition and development of the meninges remain understudied. Taking advantage of the experimental accessibility of the zebrafish, we carried out a comprehensive anatomical characterization of the fish meninges using histology, electron microscopy and super-resolution confocal microscopy of transgenic zebrafish. Like mammals, zebrafish have well-defined multi-layered meninges that contain abundant fibroblasts, endothelial, pigment, and immune cells, as well as a variety of uncharacterized cell populations. Consistently, zebrafish also possess an intracranial lymphatic network that transports immune cells and cerebrospinal fluid (CSF). We used scRNA-seq profiling of the zebrafish meninges to identify novel perivascular Fluorescent Granular Perithelial cells (FGP) and Ependymin-expressing (EPD) cell populations, both potentially important for CSF waste removal, angiogenesis, neural regeneration, and plasticity. We are further analyzing the developmental origins and functions of these cells using reporter lines and CRISPR mutants. We are also studying additional meningeal cell populations by correlating molecular and anatomical data and identifying their mammalian counterparts. Our zebrafish studies are leading to a new understanding of meningeal development and their roles in protecting the brain.

Open to the public (contact gonyerk@reed.edu for the Zoom link & password)

Event Details

0 people are interested in this event