This is a past event

Biology Seminar: Layla Oesper, “Tumor Evolution: Computational Methods for Analysis of Sequentially and Simultaneously Acquired Mutations”

This Friday's Biology Department Seminar speaker is:



Layla Oesper, Ph.D
Carleton College, Department of Computer Science

“Tumor Evolution: Computational Methods for Analysis of Sequentially and Simultaneously Acquired Mutations”


Friday, Nov 9, 2018
4:10 pm Seminar begins

Biology 19


Student Lunch: Email Kristy Gonyer at gonyerk@reed.edu if you would like to go to lunch with Dr. Oesper on Friday at noon.

Abstract: The traditional theory of cancer evolution posits that cancer genomes will acquire mutations over a long period of time as the result of an evolutionary process.   However, in recent years it has been suggested that some cancer genomes may instead undergo a one-time catastrophic event, such as chromothripsis, where a large number of mutations instead occur simultaneously.  A better understanding of how tumors development has important diagnostic and therapeutic implications.  In this talk I will describe these different models of tumor evolution and introduce computational techniques for analyzing tumor DNA sequence data according to both of these models.  In particular, I will describe a computational method that undergraduates in my lab developed to infer the evolutionary history of a tumor as a type of rooted tree given a set of plausible tumor histories.  I will also describe a measure my group developed to help distinguish cancer genomes that acquired mutations simultaneously from those where mutations were acquired sequentially. 

Additional Biology Department seminars can be found on-line, including links to some speakers' home pages at: http://academic.reed.edu/biology/seminars/index.html

Friday, November 9, 2018 at 4:10pm to 5:00pm

Biology, Biology 19
3203 Southeast Woodstock Boulevard, Portland, Oregon 97202-8199

Event Type

Lecture

Audience

Faculty, Students, Alumni, Open to the Public, Parents & Family, Staff, Prospective Students

Departments

Biology

Website

http://www.reed.edu/biology/seminars/...

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