This Friday's Biology Department Seminar speaker is:
Layla Oesper, Ph.D
Carleton College, Department of Computer Science
“Tumor Evolution: Computational Methods for Analysis of Sequentially and Simultaneously Acquired Mutations”
Friday, Nov 9, 2018
4:10 pm Seminar begins
Student Lunch: Email Kristy Gonyer at email@example.com if you would like to go to lunch with Dr. Oesper on Friday at noon.
Abstract: The traditional theory of cancer evolution posits that cancer genomes will acquire mutations over a long period of time as the result of an evolutionary process. However, in recent years it has been suggested that some cancer genomes may instead undergo a one-time catastrophic event, such as chromothripsis, where a large number of mutations instead occur simultaneously. A better understanding of how tumors development has important diagnostic and therapeutic implications. In this talk I will describe these different models of tumor evolution and introduce computational techniques for analyzing tumor DNA sequence data according to both of these models. In particular, I will describe a computational method that undergraduates in my lab developed to infer the evolutionary history of a tumor as a type of rooted tree given a set of plausible tumor histories. I will also describe a measure my group developed to help distinguish cancer genomes that acquired mutations simultaneously from those where mutations were acquired sequentially.
Additional Biology Department seminars can be found on-line, including links to some speakers' home pages at: http://academic.reed.edu/biology/seminars/index.html
Friday, November 9, 2018 at 4:10pm to 5:00pm
Biology, Biology 19
3203 Southeast Woodstock Boulevard, Portland, Oregon 97202-8199
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