Camilia Lopez-Anido, Ph.D.
Biology Department, Stanford University
“Developmental dynamics that drive cell identity and plasticity”
Friday, March 8, 2019
4:10 pm Seminar begins
Abstract: Along a developmental cell lineage trajectory, transitions from one cell identity to another are key control points – yet it remains largely unclear how these transitions are regulated. To investigate fundamental principles that direct cell fate and identity, we utilize the multipotent stomatal lineage on the epidermal surface of developing leaves from the plant model system Arabidopsis thaliana. Stomata are specialized pores comprised of two cells that are essential for atmospheric gas and water exchange. Stomatal formation is initiated by and proceeds through three discrete lineage states sequentially driven by conserved basic helix-loop-helix transcriptional regulators. To uncover additional layers of functionally heterogeneous and adaptable cell states, we are integrating single-cell systems biology with whole-tissue developmental biology and molecular genetics. Our preliminary single-cell RNA sequencing analysis indicates that cell identity is surprisingly heterogenous within the lineage, especially during the early self-renewing stages, which extends our understanding of both evolutionarily divergent and conserved pathways in stomatal development. Moving forward, we are interrogating molecular mechanisms that underlie lineage adaptability and allow for developmental flexibility in response to environmental cues.
Friday, March 8, 2019 at 4:10pm to 5:00pm
Biology, Biology 19
3203 Southeast Woodstock Boulevard, Portland, Oregon 97202-8199
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