This Friday's Biology Department Seminar is a Reed post-doc talk:
Ibrahim Youssef, Ph.D.
Reed College, Ritz Lab
“Disease Outcome Analysis via Dynamic Imaging and Multi-Platform Molecular Data Integration.”
Friday, February 17, 2017
3:50 pm - Pre-seminar tea, B-19
4:10 pm - Seminar begins, B-19
Abstract: A “disease outcome” can refer to a behavior, event, state, or condition for some aspect of a patient’s health status. For example, a behavior may correspond to drug efficacy and treatment responsiveness, while an event may correspond to patient survival. In tumors, one way to evaluate behavior is by monitoring tumor angiogenesis (formation of new blood vessels necessary for tumor to nourish itself and sustain its existence) and its vasculature permeability through dynamic imaging, in which a series of images at different time instances are acquired for a specific tumor site after injecting a contrast agent to examine tumor vasculature patterns based on accumulation and washout of the contrast agent. Observing this activity over time can reflect the tumor drug responsiveness and efficacy of the treatment plan. As for evaluating patient survival, accurate estimation of patient prognosis fosters the new era of personalized medicine through health planning, treatment strategies, and drugs customized to the individual patient rather than being chosen based on their average effect on broader population cohorts. Incorporating the underlying biology in designing the survival prediction models can provide biologically relevant insights rather than relying only on the statistical significance of the outputs. In this talk, I present my previous work on characterizing tumor angiogenesis and on designing biologically informed and integrative approaches for survival analysis by considering the integration of a set of interacting multi-platform molecular data and the underlying biology.
Any questions may be addressed directly with Professor Sarah Schaack, 2016-17 Coordinator, Biology Department Seminar Program via e-mail or phone (X7948).
Additional Biology Department seminars can be found on-line, including links to some speakers' home pages at: http://academic.reed.edu/biology/seminars/index.html
Friday, February 17, 2017 at 4:10pm
Biology, Biology 19
3203 Southeast Woodstock Boulevard, Portland, Oregon 97202-8199