This Friday's Biology Department Seminar speaker is:
Sabrice Guerrier, Ph.D.
“Identification of Novel Regulators of Selective Autophagy in Tetrahymena thermophila.”
Friday, September 29, 2017
3:50 pm Pre-seminar tea
4:10 pm Seminar begins
Student Lunch: Students interested in joining Dr. Guerrier for lunch should RSVP by emailing me ASAP since spaces are limited. Then plan to meet in B-115 shortly before noon on Friday. Commons dining room vouchers will be distributed at that time.
Abstract: Organellophagy is the selective degradation of organelles by autophagosomes. Alterations in organellophagy are associated with several disorders including neurodegeneration, heart disease, obesity, and cancer. Recent work has shown that, Nucleophagy, the selective degradation of the nucleus by autophagosomes, is up regulated in laminopathies and in response to oncogenic stress. However, it remains unclear exactly how nuclei are selected for degradation. Our primary goal is to understand the molecular mechanisms underlying how the nucleus is specifically degraded by autophagosomes. In order to uncover these mechanisms, we exploit nuclear degradation during mating in Tetrahymena thermophila. Tetrahymena selectively degrade their entire (macronucleus) nucleus in an autophagy-dependent manner as part of normal mating. Importantly, this process can be induced in the lab and occurs in predictable and identifiable stages making nucleophagy in Tetrahymena straightforward to monitor. Preliminary work in our lab has shown that nucleophagy in Tetrahymena may employ proteins involved in selective autophagy in other systems. Using both biochemical and bioinformatics approaches we plan to use this knowledge to identify novel regulators of nucleophagy in Tetrahymena with plans to test the role of such proteins in autophagy in mammalian systems.
Friday, September 29 at 4:10pm to 5:00pm
Biology, Biology 19
3203 Southeast Woodstock Boulevard, Portland, Oregon 97202-8199